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Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol by Sarah Wallace; Victoria Hall; Andre Charlett; Peter D Kirwan; Michele Cole; Natalie Gillson; Ana Atti; Jean Timeyin; Sarah Foulkes; Andrew Taylor-Kerr; Nick Andrews; Madhumita Shrotri; Sakib Rokadiya; Blanche Oguti; Amoolya Vusirikala; Jasmin Islam; Maria Zambon; Tim J G Brooks; Mary Ramsay; Colin S Brown; Meera Chand; Susan Hopkins is a Medicine article available to read on EtoBox.

What is Impact of prior SARS-CoV-2 infection and COVID-19 vaccination on the subsequent incidence of COVID-19: a multicentre prospective cohort study among UK healthcare workers – the SIREN (Sarscov2 Immunity & REinfection EvaluatioN) study protocol about?

## Introduction Understanding the effectiveness and durability of protection against SARS-CoV-2 infection conferred by previous infection and COVID-19 is essential to inform ongoing management of the pandemic. This study aims to determine whether prior SARS-CoV-2 infection or COVID-19 vaccination in healthcare workers protects against future infection. ## Methods and analysis This is a prospective cohort study design in staff members working in hospitals in the UK. At enrolment, participants are allocated into cohorts, positive or naïve, dependent on their prior SARS-CoV-2 infection status, as measured by standardised SARS-CoV-2 antibody testing on all baseline serum samples and previous SARS-CoV-2 test results. Participants undergo monthly antibody testing and fortnightly viral RNA testing during follow-up and based on these results may move between cohorts. Any results from testing undertaken for other reasons (eg, symptoms, contact tracing) or prior to study entry will also be captured. Individuals complete enrolment and fortnightly questionnaires on exposures, symptoms and vaccination. Follow-up is 12 months from study entry, with an option to extend follow-up to 24 months. The

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Author

Sarah Wallace; Victoria Hall; Andre Charlett; Peter D Kirwan; Michele Cole; Natalie Gillson; Ana Atti; Jean Timeyin; Sarah Foulkes; Andrew Taylor-Kerr; Nick Andrews; Madhumita Shrotri; Sakib Rokadiya; Blanche Oguti; Amoolya Vusirikala; Jasmin Islam; Maria Zambon; Tim J G Brooks; Mary Ramsay; Colin S Brown; Meera Chand; Susan Hopkins

Publisher

BMJ

Published

2022

Language

EN

Field

Medicine (Health Sciences)