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Can I read Fluorinated non-imidazole histamine H3 receptor antagonists on EtoBox?
Fluorinated non-imidazole histamine H3 receptor antagonists by K. Isensee; M. Amon; A. Galaparti; X. Ligneau; J.-C. Camelin; M. Capet; J.-C. Schwartz; H. Stark is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Fluorinated non-imidazole histamine H3 receptor antagonists about?
Fluorine substituents have become a widespread and important component in drug design and development. Here, the synthesis of fluorine containing compounds and some corresponding precursor molecules are presented for potential isotope labelling as well as their data obtained with in vitro and in vivo screenings. The compounds vary in the basic centres (piperidine or pyrrolidine) and are fluoro substituted in different positions of the basic alicyclic moiety. Pharmacological evaluation resulted in ligands with high affinities at hH(3) receptor in the nanomolar and subnanomolar concentration range and some with high antagonist in vivo potencies.
Who reads Fluorinated non-imidazole histamine H3 receptor antagonists?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- K. Isensee; M. Amon; A. Galaparti; X. Ligneau; J.-C. Camelin; M. Capet; J.-C. Schwartz; H. Stark
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)