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Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation by E. Yagmur; C. Trautwein; M.P.G. Leers; A.M. Gressner; F. Tacke is a Medicine article available to read on EtoBox.

What is Elevated apoptosis-associated cytokeratin 18 fragments (CK18Asp386) in serum of patients with chronic liver diseases indicate hepatic and biliary inflammation about?

## Objectives: During apoptosis, intermediate filament protein cytokeratin 18 (ck18) is cleaved by caspases at asp396 which can be specifically detected by the monoclonal antibody m30 (m30-antigen). ## Design and methods: M30-antigen serum levels were analyzed in 76 chronic liver diseases (cld) patients and 62 healthy controls. ## Results: M30-antigen levels were significantly elevated in cld patients (median 296.3 u/l) compared with healthy controls (median 153.5 u/l, p<0.001) and increased with disease severity (child-pugh or meld score). m30-antigen correlated with aminotransferase activities and parameters indicating cholestasis such as bile acids. highest serum m30-antigen was associated with histologically confirmed severe intrahepatic cholestasis (median 599.1 u/l) or biliary duct inflammation (median 648.0 u/l). furthermore, in contrast to patients with liver cirrhosis, presence of hepatocellular carcinoma was associated with elevated m30-antigen in patients without cirrhosis. ## Conclusion: Serum m30-antigen levels are elevated in cld and correlate with hepatic inflammation as well as cholangitis and cholestasis.

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Author

E. Yagmur; C. Trautwein; M.P.G. Leers; A.M. Gressner; F. Tacke

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

2007

Language

EN

Field

Medicine (Health Sciences)