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Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children by Sekkarie, Ahlia (author);Welsh, Jean A. (author);Northstone, Kate (author);Stein, Aryeh D. (author);Ramakrishnan, Usha (author);Vos, Miriam B. (author) is a Medicine article available to read on EtoBox.

What is Associations of maternal diet and nutritional status with offspring hepatic steatosis in the Avon longitudinal study of parents and children about?

## Background Priming for cardiometabolic diseases, including non-alcoholic fatty liver disease (NAFLD), is hypothesized to begin in utero. The primary objective of this study is to determine whether there is an association between maternal nutritional status and offspring NAFLD. ## Methods Data come from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the UK. The analytic sample included 3353 participants who had maternal information on pre-pregnancy BMI, gestational weight gain, diabetes, and free sugar intake as percent of total energy and were assessed for mild-severe hepatic steatosis at 24 years by transient elastography (controlled attenuation parameter score ≥ 248 dB/m). Multiple logistic regression was used to evaluate the association between maternal factors and offspring hepatic steatosis at 24 years. ## Results In confounder-adjusted models the independent associations for each maternal factor with mild to severe vs low hepatic steatosis at 24 years were: pre-pregnancy overweight (OR: 1.84, 95%CL: 1.43–2.38) or obesity (OR: 2.73, 95%CL: 1.84–4.03), more than recommended gestational weight gain (OR: 1.30, 95%CL: 1.04–1.64), diabetes (OR: 1.39, 95%CI: 0.87

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Author
Sekkarie, Ahlia (author);Welsh, Jean A. (author);Northstone, Kate (author);Stein, Aryeh D. (author);Ramakrishnan, Usha (author);Vos, Miriam B. (author)
Publisher
Springer Science and Business Media LLC
Published
2021
Language
EN
Field
Medicine (Health Sciences)

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