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Poly(amidoamine) Conjugates Containing Doxorubicin Bound via an Acid-Sensitive Linker by Nathalie Lavignac; Johanna L. Nicholls; Paolo Ferruti; Ruth Duncan is a Materials Science article available to read on EtoBox.

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## Abstract Poly(amidoamine)s with amino pendant groups were prepared by hydrogen‐transfer polyaddition of primary and secondary amines to bis‐acrylamines. Dansyl cadaverine (DC) doxorubicin (Dox) were bound to the polymers via a __cis‐__aconityl spacer to give conjugates containing 3 μg of DC per mg of polymer and 28 to 35 μg of Dox per mg of polymer. Release of DC and Dox at physiological and acidic pH varied from 0 to 35% over 48 h and was pH dependent. Although the ISA1Dox conjugate (IC~50~ = 6 μg Dox · mL^−1^) presented similar toxicity as the parent polymer without Dox, ISA23Dox showed increased toxicity (IC~50~ = 10 μg Dox · mL^−1^). These results suggest that ISA23Dox is able to release biologically active Dox __in vitro__ and that this conjugate might be suitable for further development. magnified image

Who reads Poly(amidoamine) Conjugates Containing Doxorubicin Bound via an Acid-Sensitive Linker?

Author

Nathalie Lavignac; Johanna L. Nicholls; Paolo Ferruti; Ruth Duncan

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-5187)

Published

2009

Language

EN

Field

Materials Science (Physical Sciences)