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Prognostic Significance of Thymidylate Synthase in Postoperative Non-small Cell Lung Cancer Patients by HONGYUN ZHAO; Guo-Wei Ma; Ben-Yan Zou; Mei Li; Su-Xia Lin; Li-Ping Zhao; Ying Guo; YAN HUANG; Ying Tian; Dan Xie; Li Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The aim of the present study was to investigate the clinicopathologic/prognostic significance of thymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT), and thymidine phosphorylase (TP) proteins in postoperative non-small cell lung cancer (NSCLC) patients. Microarray slides from a set of 178 NSCLC patients were used for the detection of TS, OPRT, and TP expression by immunohistochemistry. The correlation between clinicopathologic factors and protein expression of three proteins was analyzed. Ninety seven carcinomas (57.4%) were TS-positive, 90 carcinomas (53.9%) were OPRT-positive, and 102 carcinomas (69.4%) were TP-positive. Compared with the TS-positive patients, the overall survival (OS) was significantly lower in the TS-negative patients (hazard ratio [HR] =1.766, 95% confidence interval [CI] =1.212–2.573, __P__=0.003). Significant differences between TS-positive and TS-negative patients was also observed in the following stratified analyses: 1) adenocarcinoma subgroup (HR =2.079, 95% CI =1.235–3.500, __P__=0.006); 2) less than 60-year-old subgroup (HR =1.890, 95% CI =1.061–3.366, __P__=0.031); 3) stage II/III subgroup (HR =1.594, 95% CI =1.036–2.453, __P__=0.034);

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Author

HONGYUN ZHAO; Guo-Wei Ma; Ben-Yan Zou; Mei Li; Su-Xia Lin; Li-Ping Zhao; Ying Guo; YAN HUANG; Ying Tian; Dan Xie; Li Zhang

Publisher

Informa UK Limited

Published

2014

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)