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Impact of residual inflammation on myocardial recovery and cardiovascular outcome in Takotsubo patients by LachmetâThebaud, Lucie; Marchandot, Benjamin; Matsushita, Kensuke; Sato, Chisato; Dagrenat, Charlotte; Greciano, Stephane; De Poli, Fabien; Leddet, Pierre; Peillex, Marilou; Hess, Sébastien; Carmona, Adrien; Jimenez, Charline; Heger, Joe; Reydel, Antje; Ohlmann, Patrick; Jesel, Laurence; Morel, Olivier is a Medicine article available to read on EtoBox.

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## Abstract ## Aims Recent insights have emphasized the importance of myocardial and systemic inflammation in Takotsubo syndrome (TTS). In a large registry of unselected patients, we sought to evaluate whether residual high inflammatory response (RHIR) could impact cardiovascular outcome after TTS. ## Methods and results Patients with TTS were retrospectively included between 2008 and 2018 in three general hospitals. Three hundred eighty‐five patients with TTS were split into three subgroups, according to tertiles of C‐reactive protein (CRP) levels at discharge (CRP 19 mg/L). The primary endpoint was the impact of RHIR, defined as CRP >19 mg/L at discharge, on cardiac death or hospitalization for heart failure. Follow up was obtained in 382 patients (99%) after a median of 747 days. RHIR patients were more likely to have a history of cancer or a physical trigger. Left ventricular ejection fraction (LVEF) at admission and at discharge were comparable between groups. By contrast, RHIR was associated with lower LVEF at follow up (61.7% vs. 60.7% vs. 57.9%; __P__ = 0.004) and increased cardiac late mortality (0% vs. 0% vs. 10%; __P__ = 0.001). By multivariate Cox regression analysis,

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Author

LachmetâThebaud, Lucie; Marchandot, Benjamin; Matsushita, Kensuke; Sato, Chisato; Dagrenat, Charlotte; Greciano, Stephane; De Poli, Fabien; Leddet, Pierre; Peillex, Marilou; Hess, Sébastien; Carmona, Adrien; Jimenez, Charline; Heger, Joe; Reydel, Antje; Ohlmann, Patrick; Jesel, Laurence; Morel, Olivier

Publisher

Wiley (John Wiley & Sons); The Heart Failure Association of the European Society of Cardiology; [Oxford]: published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology, 2014-; Wiley (ISSN 2055-5822)

Published

2020

Language

EN

Field

Medicine (Health Sciences)