Can I read Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model on EtoBox?

Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model by Kevin Knoernschild; Hans J. Johnson; Kimberly E. Schroeder; Vicki J. Swier; Katherine A. White; Takashi S. Sato; Christopher S. Rogers; Jill M. Weimer; Jessica C. Sieren is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model about?

Late-infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease (Batten disease) is a rare pediatric disease, with symptom development leading to clinical diagnosis. Early diagnosis and effective tracking of disease progression are required for treatment. We hypothesize that brain volumetry is valuable in identifying CLN2 disease at an early stage and tracking disease progression in a genetically modified miniswine model. __CLN2__^__R208X/R208X__^ miniswine and wild type controls were evaluated at 12- and 17-months of age, correlating to early and late stages of disease progression. Magnetic resonance imaging (MRI) T1- and T2-weighted data were acquired. Total intercranial, gray matter, cerebrospinal fluid, white matter, caudate, putamen, and ventricle volumes were calculated and expressed as proportions of the intracranial volume. The brain regions were compared between timepoints and cohorts using Gardner-Altman plots, mean differences, and confidence intervals. At an early stage of disease, the total intracranial volume (− 9.06 cm^3^), gray matter (− 4.37% 95 CI − 7.41; − 1.83), caudate (− 0.16%, 95 CI − 0.24; − 0.08) and putamen (− 0.11% 95 CI − 0.23; − 0.02) were all notab

Who reads Magnetic resonance brain volumetry biomarkers of CLN2 Batten disease identified with miniswine model?

Author

Kevin Knoernschild; Hans J. Johnson; Kimberly E. Schroeder; Vicki J. Swier; Katherine A. White; Takashi S. Sato; Christopher S. Rogers; Jill M. Weimer; Jessica C. Sieren

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)