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Can I read ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms on EtoBox?
ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms by Qiangwei Zhou; Pengpeng Guan; Zhixian Zhu; Sheng Cheng; Cong Zhou; Huanhuan Wang; Qian Xu; Wing-kin Sung; Guoliang Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms about?
## Abstract DNA methylation is known to be the most stable epigenetic modification and has been extensively studied in relation to cell differentiation, development, X chromosome inactivation and disease. Allele-specific DNA methylation (ASM) is a well-established mechanism for genomic imprinting and regulates imprinted gene expression. Previous studies have confirmed that certain special regions with ASM are susceptible and closely related to human carcinogenesis and plant development. In addition, recent studies have proven ASM to be an effective tumour marker. However, research on the functions of ASM in diseases and development is still extremely scarce. Here, we collected 4400 BS-Seq datasets and 1598 corresponding RNA-Seq datasets from 47 species, including human and mouse, to establish a comprehensive ASM database. We obtained the data on DNA methylation level, ASM and allele-specific expressed genes (ASEGs) and further analysed the ASM/ASEG distribution patterns of these species. In-depth ASM distribution analysis and differential methylation analysis conducted in nine cancer types showed results consistent with the reported changes in ASM in key tumour genes and revealed s
Who reads ASMdb: a comprehensive database for allele-specific DNA methylation in diverse organisms?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Qiangwei Zhou; Pengpeng Guan; Zhixian Zhu; Sheng Cheng; Cong Zhou; Huanhuan Wang; Qian Xu; Wing-kin Sung; Guoliang Li
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)