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Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia by Takayuki Ikezoe; Shinsuke Kojima; Mutsuo Furihata; Jing Yang; Chie Nishioka; Asako Takeuchi; Mayuka Isaka; H. Phillip Koeffler; Akihito Yokoyama is a Medicine article available to read on EtoBox.
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## Abstract Our study determined if Janus kinase 2 (JAK2) was activated in acute myelogenous leukemia (AML; __n__ = 77, excluding acute promyelocytic leukemia) by immunohistochemistry (IHC) using a phosphor‐specific antibody against JAK2. p‐JAK2 was detectable in all cases, although its levels varied between patient samples (high levels, __n__ = 31; low levels, __n__ = 46). The quantification of levels of p‐JAK2 by IHC was well correlated with that assessed by Western blot analyses and fluorescence‐activated cell sorting (FACS). Levels of p‐JAK2 were directly correlated with high white blood cell count (52.3 × 10^3^/L in patients with high p‐JAK2 __vs__. 28.3 × 10^3^/L in patients with low p‐JAK2, __p__ < 0.01) and were inversely correlated with complete remission rates (45% in patients with high p‐JAK2 __vs__. 78% in patients with low p‐JAK2, __p__ < 0.003). In addition, multivariate analysis confirmed that high levels of p‐JAK2 remained a significant factor for overall survival (hazard ratio = 2.213; 95% confidence interval, 1.212–4.041, __p__ = 0.023). Moreover, we found that AZ960, a novel and specific inhibitor of the JAK2 kinase, potently inhibited the clonogenic growth and i
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- Author
- Takayuki Ikezoe; Shinsuke Kojima; Mutsuo Furihata; Jing Yang; Chie Nishioka; Asako Takeuchi; Mayuka Isaka; H. Phillip Koeffler; Akihito Yokoyama
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)