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Increased Interleukin-6 levels in pituitary-deficient patients are independently related to their carotid intima-media thickness by M. Leonsson; J. Hulthe; G. Johannsson; O. Wiklund; J. Wikstrand; B. Å. Bengtsson; J. Oscarsson is a Medicine article available to read on EtoBox.
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## Summary **objective** Increased cardiovascular morbidity and mortality has been observed in patients with pituitary deficiency and untreated growth hormone deficiency (GHD). We investigated peripheral inflammatory and fibrinolytic markers and their associations with arterial intima‐media thickness (IMT) in GHD. **design** Cross‐sectional study. **patients** Thirty‐four patients with GHD, but without cardiovascular disease, were compared to healthy controls matched for age, sex, body mass index (BMI) and smoking habits. **measurements** IMT of the common carotid artery, C‐reactive protein (CRP), interleukin‐6 (IL‐6), fibrinogen, plasminogen activator inhibitor‐1 (PAI‐1) activity and tissue plasminogen activator antigen (tPA‐ag) were measured. **results** Median IL‐6 concentrations were increased by 208% and 248% in GHD patients compared to BMI‐matched and nonobese controls, respectively. Median CRP and tPA‐ag levels were increased by 237% and 167% in patients compared to nonobese controls, but not significantly different compared to BMI‐matched controls. Plasma levels of fibrinogen and PAI‐1 activity did not differ between groups. Age, low‐density lipoprotein (LDL) cholesterol, t
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- Author
- M. Leonsson; J. Hulthe; G. Johannsson; O. Wiklund; J. Wikstrand; B. Å. Bengtsson; J. Oscarsson
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)