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Can I read Regulation of Translation in the Protozoan Parasite Leishmania on EtoBox?
Regulation of Translation in the Protozoan Parasite Leishmania by Zemfira N. Karamysheva; Sneider Alexander Gutierrez Guarnizo; Andrey L. Karamyshev is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Regulation of Translation in the Protozoan Parasite Leishmania about?
Leishmaniasis represents a serious health problem worldwide and drug resistance is a growing concern. __Leishmania__ parasites use unusual mechanisms to control their gene expression. In contrast to many other species, they do not have transcriptional regulation. The lack of transcriptional control is mainly compensated by post-transcriptional mechanisms, including tight translational control and regulation of mRNA stability/translatability by RNA-binding proteins. Modulation of translation plays a major role in parasite survival and adaptation to dramatically different environments during change of host; however, our knowledge of fine molecular mechanisms of translation in __Leishmania__ remains limited. Here, we review the current progress in our understanding of how changes in the translational machinery promote parasite differentiation during transmission from a sand fly to a mammalian host, and discuss how translational reprogramming can contribute to the development of drug resistance.
Who reads Regulation of Translation in the Protozoan Parasite Leishmania?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zemfira N. Karamysheva; Sneider Alexander Gutierrez Guarnizo; Andrey L. Karamyshev
- Publisher
- Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI Center, 2000- (ISSN 1422-0067)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)