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Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases by Hiroaki Yamagamim; Mitsuhiko Moriyama; Hiroshi Matsumura; Hiroshi Aoki; Toshihiro Shimizu; Takahide Saito; Miki Kaneko; Atsuo Shioda; Naohide Tanaka; Yasuyuki Arakawa is a Medicine article available to read on EtoBox.
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## Background: Numerous reports have examined the relationship between hepatocyte growth factor (hgf) and either the facilitation or suppression of the occurrence of hepatocellular carcinoma (hcc). ## Methods: In this study, we measured serum hgf concentrations of blood samples and conducted prospective studies to examine the long-term outcome of c-viral chronic hepatitis (ch) and cirrhosis in patients. the subjects examined in this study include 99 patients with c-viral ch, cirrhosis, and hcc. the serum hgf level was measured in blood samples within 48 hours of collection using enzyme-linked immunosorbent assay kits. ## Results: The serum concentrations of hgf were significantly higher in patients with hcc than in patients with ch or cirrhosis. the detection rate of hgf and its mean serum level were significantly higher in patients with a low platelet count than in patients with a high platelet count. all of the patients with serum hgf concentrations of more than 0.6 ng/ml had hcc, irrespective of the levels of alpha-fetoprotein, vitamin k absence, or antagonist-ii in the blood. serum hgf concentrations increased concomitantly with increases in areas occupied by hcc. the cumulativ
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- Author
- Hiroaki Yamagamim; Mitsuhiko Moriyama; Hiroshi Matsumura; Hiroshi Aoki; Toshihiro Shimizu; Takahide Saito; Miki Kaneko; Atsuo Shioda; Naohide Tanaka; Yasuyuki Arakawa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)