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In Situ Chondrocyte Deformation with Physiological Compression of the Feline Patellofemoral Joint by A.L. Clark; L.D. Barclay; J.R. Matyas; W. Herzog is a Medicine article available to read on EtoBox.

What is In Situ Chondrocyte Deformation with Physiological Compression of the Feline Patellofemoral Joint about?

The mechanical environment is an important factor affecting the maintenance and adaptation of articular cartilage, and thus the function of the joint and the progression of joint degeneration. Recent evidence suggests that cartilage deformation caused by mechanical loading is directly associated with deformation and volume changes of chondrocytes. Furthermore, in vitro experiments have shown that these changes in the mechanical states of chondrocytes correlate with a change in the biosynthetic activity of cartilage cells. The purpose of this study was to apply our knowledge of contact forces within the feline patellofemoral joint to quantify chondrocyte deformation in situ under loads of physiological magnitude. A uniform, static load of physiological magnitude was applied to healthy articular cartilage still fully intact and attached to its native bone. The compressed cartilage was then chemically fixed to enable the evaluation of cartilage strain, chondrocyte deformation and chondrocyte volumetric fraction. Patella and femoral groove articular cartilages differ in thickness, chondrocyte aspect ratio, and chondrocyte volumetric fraction in both magnitude and depth distribution. Fu

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Author

A.L. Clark; L.D. Barclay; J.R. Matyas; W. Herzog

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)

Published

2003

Language

EN

Field

Medicine (Health Sciences)