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Antioxidant Potential of Aqueous Dispersions of Fullerenes C~60~, C~70~, and Gd@C~82~ by Ivan V. Mikheev; Madina M. Sozarukova; Dmitry Yu. Izmailov; Ivan E. Kareev; Elena V. Proskurnina; Mikhail A. Proskurnin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The antioxidant potential (capacity and activity) of aqueous fullerene dispersions (AFD) of non-functionalized C60, C70, and Gd@C82 endofullerene (in micromolar concentration range) was estimated based on chemiluminescence measurements of the model of luminol and generation of organic radicals by 2,2′-azobis(2-amidinopropane) dihydrochloride (ABAP). The antioxidant capacity was estimated by the TRAP method, from the concentration of half-suppression, and from the suppression area in the initial period. All three approaches agree and show that the antioxidant capacity of AFDs increased in the order Gd@C82 < C70 < C60. Mathematical modeling of the long-term kinetics data was used for antioxidant activity estimation. The effect of C60 and C70 is found to be quenching of the excited product of luminol with ABAP-generated radical and not an actual antioxidant effect; quenching constants differ insignificantly. Apart from quenching with a similar constant, the AFD of Gd@C82 exhibits actual antioxidant action. The antioxidant activity in Gd@C82 is 300-fold higher than quenching constants.

Who reads Antioxidant Potential of Aqueous Dispersions of Fullerenes C~60~, C~70~, and Gd@C~82~?

Author

Ivan V. Mikheev; Madina M. Sozarukova; Dmitry Yu. Izmailov; Ivan E. Kareev; Elena V. Proskurnina; Mikhail A. Proskurnin

Publisher

MDPI AG

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)