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Peripheral and Spinal Mechanisms of Nociception by Eduardo E. Benarroch is a book available to read on EtoBox.

What is Peripheral and Spinal Mechanisms of Nociception about?

Pain is a conscious subjective experience driven by activity of nociceptors. Pain includes not only nociception but also abnormal transmission and processing of painful stimuli. Nociception involves unmyelinated and small myelinated fibers from small dorsal root ganglion neurons that respond to noxious heat, mechanical, or chemically stimuli. These neurons are functional and biochemically heterogeneous in terms of their sensitivity to stimuli, type of afferent axons, neurochemical composition, and targets in the dorsal horn. They activate both second-order projection neurons and different subsets of excitatory and inhibitory interneurons that have a major role in processing of sensory information. Mutations affecting ion channels in nociceptors, inflammatory mediators, or peripheral nerve injury trigger changes and expression of ion channels and receptors. This results in increased excitability of nociceptors, known as peripheral sensitization. Abnormal activity in nociceptors triggers plastic channels in the dorsal horn resulting in altered balance between excitation and inhibition, resulting in central sensitization. Local activation of microglia and astrocytes plays a major role

Author

Eduardo E. Benarroch

Publisher

Oxford University Press

Published

2021

Language

EN