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Induction of DNA double-strand breaks in mammalian cells and yeast by D. Frankenberg; H.J. Brede; U.J. Schrewe; Ch. Steinmetz; M. Frankenberg-Schwager; G. Kasten; E. Pralle is a Physics and Astronomy article available to read on EtoBox.

What is Induction of DNA double-strand breaks in mammalian cells and yeast about?

Induction of DNA double-strand breaks (dsb) and their distribution are dependent on the energy deposition pattern within the cell nucleus (physical structure) and the ultrastructure of the chromosomes and its variation by the cell cycle and gene activities (biological structure). For electron radiation very similar RBE-values are observed for mammalian and yeast cells (Al,; 1.5 keV, 15 keV/l.tm: 2.6 in mammalian cells and 2.2 in yeast; C,, 0.278 keV, 23 keV/pm: approx. 2.5 in mammalian cells and 3.8 in yeast). In contrast, the RBE-values for the induction of dsb of "He\*' and light ions in the LET range from about 100 keV/pm up to 1000 keV/pm are significantly higher for yeast cells compared to mammalian cells. For example, the RBE-value of &particles (120 keV/pm) is about 1.2 for mammalian cells whereas for yeast the RBE-value is about 2.5. The yeast chromatin has less condensed fibres compared with mammalian cells. Since a single C, photoelectron can induce only one dsb, the different condensation of the mammalian and yeast chromatin has no influence. However, particles may induce more than one dsb when traversing a chromatin fibre. The probability for the induction of closely ne

Who reads Induction of DNA double-strand breaks in mammalian cells and yeast?

Author

D. Frankenberg; H.J. Brede; U.J. Schrewe; Ch. Steinmetz; M. Frankenberg-Schwager; G. Kasten; E. Pralle

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0273-1177)

Published

2000

Language

EN

Field

Physics and Astronomy (Physical Sciences)