About this Medicine article
Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion by Jessica B. Felix; Aaron R. Cox; Sean M. Hartig is a Medicine article available to read on EtoBox.
White adipose tissue (WAT) depends on coordinated regulation of transcriptional and metabolic pathways to respond to whole-body energy demands. We highlight metabolites that contribute to biosynthetic reactions for WAT expansion. Recent studies have precisely defined how byproducts of carbohydrate and lipid metabolism affect physiological and endocrine functions in adipocytes. We emphasize the critical emerging roles of short-chain fatty acids (SCFAs) and tricarboxylic acid (TCA) cycle metabolites that connect lipogenesis to WAT energy balance and endocrine functions. These insights address how adipocytes use small molecules generated from central carbon metabolism to measure responses to nutritional stress. ## The Metabolically Protective Effects of WAT Obesity reflects excessive expansion of WAT and frequently promotes multiple comorbidities, including insulin resistance, systemic inflammation, nonalcoholic fatty liver disease (NAFLD), and cardiovascular disease [1]. In systemic insulin resistance, insulin does not adequately drive glucose import into adipocytes or oppose lipolysis sufficiently to protect non-adipose tissues from ectopic lipid deposition. For example, unopposed l
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- Author
- Jessica B. Felix; Aaron R. Cox; Sean M. Hartig
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)