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Calcium Homeostasis: A Potential Vicious Cycle of Bone Metastasis in Breast Cancers by Yang, Zhengfeng; Yue, Zhiying; Ma, Xinrun; Xu, Zhenyao is a Medicine article available to read on EtoBox.

What is Calcium Homeostasis: A Potential Vicious Cycle of Bone Metastasis in Breast Cancers about?

Cancers have been considered as one of the most severe health problems in the world. Efforts to elucidate the cancer progression reveal the importance of bone metastasis for tumor malignancy, one of the leading causes for high mortality rate. Multiple cancers develop bone metastasis, from which breast cancers exhibit the highest rate and have been well-recognized. Numerous cells and environmental factors have been believed to synergistically facilitate bone metastasis in breast cancers, from which breast cancer cells, osteoclasts, osteoblasts, and their produced cytokines have been well-recognized to form a vicious cycle that aggravates tumor malignancy. Except the cytokines or chemokines, calcium ions are another element largely released from bones during bone metastasis that leads to hypercalcemia, however, have not been well-characterized yet in modulation of bone metastasis. Calcium ions act as a type of unique second messenger that exhibits omnipotent functions in numerous cells, including tumor cells, osteoclasts, and osteoblasts. Calcium ions cannot be produced in the cells and are dynamically fluxed among extracellular calcium pools, intracellular calcium storages and cytos

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Author

Yang, Zhengfeng; Yue, Zhiying; Ma, Xinrun; Xu, Zhenyao

Publisher

Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2011- (ISSN 2234-943X)

Published

2020

Language

EN

Field

Medicine (Health Sciences)