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The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification by Laura Sheard; Nat MJ Wright; Hany G El-Sayeh; Clive E Adams; Ryan Li; Charlotte NE Tompkins is a Medicine article available to read on EtoBox.
What is The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification about?
## Background: Many opiate users entering british prisons require prescribed medication to help them achieve abstinence. this commonly takes the form of a detoxification regime. previously, a range of detoxification agents have been prescribed without a clear evidence base to recommend a drug of choice. there are few trials and very few in the prison setting. this study compares dihydrocodeine with buprenorphine. ## Methods: Open label, pragmatic, randomised controlled trial in a large remand prison in the north of england. ninety adult male prisoners requesting an opiate detoxification were randomised to receive either daily sublingual buprenorphine or daily oral dihydrocodeine, given in the context of routine care. all participants gave written, informed consent. reducing regimens were within a standard regimen of not more than 20 days and were at the discretion of the prescribing doctor. primary outcome was abstinence from illicit opiates as indicated by a urine test at five days post detoxification. secondary outcomes were collected during the detoxification period and then at one, three and six months post detoxification. analysis was undertaken using relative risk tests for c
Who reads The Leeds Evaluation of Efficacy of Detoxification Study (LEEDS) prisons project: a randomised controlled trial comparing dihydrocodeine and buprenorphine for opiate detoxification?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Laura Sheard; Nat MJ Wright; Hany G El-Sayeh; Clive E Adams; Ryan Li; Charlotte NE Tompkins
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, c2006-; Springer Science and Business Media LLC (ISSN 1747-597X)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)