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Differential expression of c‐jun and c‐fos mRNAs in squamous cell carcinoma of the head and neck: Associations with uPA, gelatinase B, and matrilysin mRNAs by Mercia Medeiros Pacheco; Luis Paulo Kowalski; Ines Nobuko Nishimoto; Maria Mitzi Brentani is a Medicine article available to read on EtoBox.
What is Differential expression of c‐jun and c‐fos mRNAs in squamous cell carcinoma of the head and neck: Associations with uPA, gelatinase B, and matrilysin mRNAs about?
## Abstract ## Background Head and neck squamous cell carcinomas (HNSCC) are known for their invasive behavior. The invasiveness of these tumors requires proteases, some of which as urokinase‐type plasminogen activator (uPA), gelatinase B and matrilysin are regulated through AP‐1 dependent transcriptional mechanisms. AP‐1 consists of several proteins, including those encoded by the proto‐oncogenes __c‐jun__ and __c‐fos__. The aim of this study was to: first, evaluate the expression levels of matrix metalloproteases (matrilysin and gelatinase B) and uPA mRNAs; second, examine whether these genes might be associated with __c‐jun__ and __c‐fos__ expression; third, examine the relationship between the expression of these genes and HNSCC clinico‐pathological features. ## Methods We have analyzed 38 HNSCC primary tumors and matched mucosa tissues for uPA, gelatinase B, matrilysin, __c‐fos__, and __c‐jun__ by Northern‐blot analysis. ## Results uPA, gelatinase B, matrilysin, and __c‐jun__ mean levels were statistically higher in the tumors than in the normal adjacent mucosa, whereas no difference was found when __c‐fos__ mRNA values were compared, __c‐jun__ mRNA expression correlated direc
Who reads Differential expression of c‐jun and c‐fos mRNAs in squamous cell carcinoma of the head and neck: Associations with uPA, gelatinase B, and matrilysin mRNAs?
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- Author
- Mercia Medeiros Pacheco; Luis Paulo Kowalski; Ines Nobuko Nishimoto; Maria Mitzi Brentani
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)