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D‐methylphenidate and D,L‐methylphenidate are not developmental toxicants in rats and rabbits by Steve K. Teo; David I. Stirling; Alan M. Hoberman; Mildred S. Christian; Steve D. Thomas; Vikram D. Khetani is a Medicine article available to read on EtoBox.
What is D‐methylphenidate and D,L‐methylphenidate are not developmental toxicants in rats and rabbits about?
## Abstract **BACKGROUND:** D,L‐__threo__‐Methylphenidate (D,L‐MPH) is marketed currently for attention deficit hyperactivity disorder in children. D‐__threo__‐methylphenidate (dexmethylphenidate; D‐MPH) is a refined formulation of D,L‐methylphenidate containing only the active enantiomer and was recently approved in the U.S. for the same condition. D‐Methylphenidate has been shown to be efficacious in patients at half the dose of D,L‐MPH with a potentially improved therapeutic profile. The developmental toxicity of both compounds was determined and compared in rats and rabbits according to current International Conference on Harmonization (ICH) guidelines. **METHODS:** Groups of pregnant rats were orally dosed twice daily 6 hr apart from Days 7 to 17 of presumed gestation (DG 7–17) for total daily doses of 2, 6 and 20 mg/kg D‐MPH and 40 mg/kg D,L‐MPH. Groups of presumed pregnant rabbits were similarly dosed from DG 6 to 18 for total daily doses of 4, 20 and 100 mg/kg D‐MPH and 200 mg/kg D,L‐MPH. Control groups for both studies were given water vehicle. Comprehensive clinical and developmental measurements were made. Satellite groups of animals were included in the main rat and rab
Who reads D‐methylphenidate and D,L‐methylphenidate are not developmental toxicants in rats and rabbits?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Steve K. Teo; David I. Stirling; Alan M. Hoberman; Mildred S. Christian; Steve D. Thomas; Vikram D. Khetani
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1542-9733)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)