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Expression of Bcl ‐2 Oncoprotein in Renal Cell Tumours by François Paraf; Jean Gogusev; Yves Chrétien; Dominique Droz is a Medicine article available to read on EtoBox.

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## Abstract Expression of __bcl__‐2 is associated with inhibition of apoptosis and extension of cell survival. The importance of apoptosis in relation to the development and progression of renal cell neoplasia remains undefined so far. In order to determine the expression of __bcl__‐2 oncoprotein in normal and neoplastic renal cells, 37 renal tumours were investigated by immunolabelling, including 13 clear cell carcinomas, ten tubulopapillary carcinomas, four chromophobic renal cell carcinomas, and ten oncocytomas. Twenty‐six samples of adjacent normal renal tissue served as controls. __bcl__‐2 expression was correlated with cell proliferation activity as estimated by Ki67 antigen expression, and p53 protein expression in the tumour samples. The results demonstrate that in the normal kidney, positive __bcl__‐2 immunostaining was present in glomerular parietal epithelial cells, in distal tubular cells, and in sparse proximal tubule cells. Renal cell tumours showed heterogeneous __bcl__‐2 expression according to the tumour cell type. While the majority of carcinomas of clear cell type were usually negative or contained sparsely distributed positive cells, all tubulopapillary carcinom

Who reads Expression of Bcl ‐2 Oncoprotein in Renal Cell Tumours?

Author

François Paraf; Jean Gogusev; Yves Chrétien; Dominique Droz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1995

Language

EN

Field

Medicine (Health Sciences)