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Validation and Performance of FibroScan®-AST (FAST) Score on a Brazilian Population with Nonalcoholic Fatty Liver Disease by Ana Carolina Cardoso; Cristiane Valle Tovo; Nathalie Carvalho Leite; Ibrahim A. El Bacha; Fernanda Luiza Calçado; Gabriela Perdomo Coral; Glauco Navas Sammarco; Claudia Cravo; Roberto José Carvalho Filho; Renata de Mello Perez; Ronir Raggio Luiz; Edison Roberto Parise; Cristiane A. Villela-Nogueira is a Medicine article available to read on EtoBox.
What is Validation and Performance of FibroScan®-AST (FAST) Score on a Brazilian Population with Nonalcoholic Fatty Liver Disease about?
## Background and aim: Fast score has a good performance for diagnosing the composite of nash + nas ≥ 4 + f ≥ 2. however, it has not been evaluated in latin american individuals with nonalcoholic fatty liver disease (nafld). we aimed to analyze the performance of the fast score in a brazilian nafld population. ## Methods: Cross-sectional study was held in ≥ 18 years nafld patients diagnosed by ultrasonography and submitted to liver biopsy (lb). liver stiffness (lsm) and cap measurements were performed with fibroscan®, using m (bmi < 32 kg/m) or xl probes. area under receiver operating characteristic (auroc) curves were calculated as well as sensitivity (s), specificity (spe), positive predictive value (vpp) and negative predictive value (npv) for the previously established fast score cut-offs. ## Results: Among 287 patients included (75% female; mean age 55 ± 10 years), nash + nas ≥ 4 + f ≥ 2 was reported in 30% of lb. for the fast cut-off of 0.35, the s and npv to rule out nash + nas ≥ 4 + f ≥ 2 were 78.8% and 87.8%, respectively. regarding the cut-off of 0.67, the spe and ppv to rule-in nash + nas ≥ 4 + f ≥ 2 were 89.1%, 61.8%, respectively. the auroc of fast for all included pat
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- Author
- Ana Carolina Cardoso; Cristiane Valle Tovo; Nathalie Carvalho Leite; Ibrahim A. El Bacha; Fernanda Luiza Calçado; Gabriela Perdomo Coral; Glauco Navas Sammarco; Claudia Cravo; Roberto José Carvalho Filho; Renata de Mello Perez; Ronir Raggio Luiz; Edison Roberto Parise; Cristiane A. Villela-Nogueira
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)