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Can I read Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors on EtoBox?
Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors by Hubert Josien; Thomas Bara; Murali Rajagopalan; Theodros Asberom; John W. Clader; Leonard Favreau; William J. Greenlee; Lynn A. Hyde; Amin A. Nomeir; Eric M. Parker; Dmitri A. Pissarnitski; Lixin Song; Gwendolyn T. Wong; Lili Zhang; Qi Zhang; Zhiqiang Zhao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors about?
The design and development of a new class of small 2,6-disubstituted piperidine N-arylsulfonamide gamma-secretase inhibitors is reported. Lowering molecular weight including the use of conformational constraint led to compounds with less CYP 3A4 liability compared to early leads. Compounds active orally in lowering Abeta levels in Tg CRND8 mice were identified as potential treatments for Alzheimer's disease.
Who reads Small conformationally restricted piperidine N-arylsulfonamides as orally active γ-secretase inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hubert Josien; Thomas Bara; Murali Rajagopalan; Theodros Asberom; John W. Clader; Leonard Favreau; William J. Greenlee; Lynn A. Hyde; Amin A. Nomeir; Eric M. Parker; Dmitri A. Pissarnitski; Lixin Song; Gwendolyn T. Wong; Lili Zhang; Qi Zhang; Zhiqiang Zhao
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)