Can I read The Efficacy and Safety of Perioperative Glucocorticoid for Total Knee Arthroplasty: a Systematic Review and Meta-analysis on EtoBox?

The Efficacy and Safety of Perioperative Glucocorticoid for Total Knee Arthroplasty: a Systematic Review and Meta-analysis by Fangyan Liu; Mei Duan; Huiqun Fu; Tianlong Wang is a Medicine article available to read on EtoBox.

What is The Efficacy and Safety of Perioperative Glucocorticoid for Total Knee Arthroplasty: a Systematic Review and Meta-analysis about?

## Abstract ## Background An increasing number of individuals undergo total knee arthroplasty (TKA), which can result in pain, limited motor function and adverse complications such as infection, nausea and vomiting. Glucocorticoids have been shown anti-inflammatory and antiemetic effects, but can also elevate blood glucose levels and increase the risk of wound infection. Thus, it is essential to investigate the efficacy and safety of glucocorticoid usage in TKA. ## Method A comprehensive systematic search of PubMed, Medline, EMBASE, Cochrane databases, to identify relevant randomized controlled trials (RCTs) of glucocorticoid application in TKA. The primary outcomes assessed were the postoperative pain assessment. Secondary outcomes included the range of motion in knee joint, levels of inflammatory cytokines, adverse complications, and the length of hospital stay. ## Results Thirty-six randomized controlled trials were included in the final analysis. The glucocorticoid group exhibited significant reduction in the resting VAS scores on postoperative days 1, 2 (POD1, 2)and postoperative 3 months (POM3), as well as decreased morphine consumption on POD1 and increased range of motion (

Who reads The Efficacy and Safety of Perioperative Glucocorticoid for Total Knee Arthroplasty: a Systematic Review and Meta-analysis?

Author

Fangyan Liu; Mei Duan; Huiqun Fu; Tianlong Wang

Publisher

Springer Science and Business Media LLC

Published

2024

Language

EN

Field

Medicine (Health Sciences)