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Evaluation of DNA topoisomerase IIα expression provides independent prognostic information in non-Hodgkin's lymphomas by P Korkolopoulou; M Angelopoulou; M Siakantari; F Mitropoulos; T Vassilakopoulos; H Zorzos; G Rassidakis; A Androulaki; E Patsouris; C Kittas; P Davaris; G A Pangalis is a Medicine article available to read on EtoBox.

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## Aims: In view of the dual role that dna topoisomerase iia (topoiia) plays as a cell proliferation marker and as a possible indicator of chemosensitivity, we investigated its expression in non-hodgkin's lymphomas (nhl) in relation to conventional clinicopathological parameters, cell proliferation (as defined by ki67 immunoreactivity), response to therapy and patient outcome. ## Methods and results: Formalin-fixed paraffin-embedded tissues from 153 patients with nhl were immunohistochemically stained for topoiialpha. patients were followed up until death (n = 63) or for an average of 68 months (median 64 months, n = 90). the percentage of topoiialpha positive cells (topoiialpha li) increased with grade (p < 0.001), extranodal location (p = 0.05) and ki67 li (p = 0.01, r = 0.673). in most cases (58%), ki67 li exceeded topoiialpha li (topoiialpha/ki67 < 1), especially within the indolent group (p < 0.001). topoiialphali, ki67li and topoiialpha/ki67 ratio were all adversely related to overall survival in univariate analysis, though their significance was not maintained after adjustment for grade. in multivariate analysis high topoiialpha/ki67 ratio and high topoiialpha li independent

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Author

P Korkolopoulou; M Angelopoulou; M Siakantari; F Mitropoulos; T Vassilakopoulos; H Zorzos; G Rassidakis; A Androulaki; E Patsouris; C Kittas; P Davaris; G A Pangalis

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0309-0167)

Published

2001

Language

EN

Field

Medicine (Health Sciences)