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<p>Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.<br> Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors-providing the pharmacological information needed to solve treatment problems and facilitate the drug design process!<br> Demonstrating the achievements of the receptor-based approach in therapeutics and indicating future directions, Receptor-Based Drug Design</p> <ul class="noindent"> <li>introduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptors<br> </li> <li>shows how to assess agonist concentration-effect curve data<br> </li> <li>discusses radioligand binding assays<br> </li> <li>presents new in vitro multiarray assays for G-protein-coupled receptors<br> </li> <li>explains the use of individual second messenger signaling responses in analyzing drug-receptor interactions<br> </li> <li>examines the role of electrophysi
- Author
- Leff;Paul.
- Publisher
- Marcel Dekker Incorporated
- Published
- 1998
- Language
- EN
- ISBN
- 9780824701628
- Subjects
- Medical, Science, Chemistry
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