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Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals by Ei. Christodoulou; N.P.E. Kadoglou; M. Stasinopoulou; O.A. Konstandi; C. Kenoutis; Z.I. Kakazanis; A. Rizakou; N. Kostomitsopoulos; G. Valsami is a Medicine article available to read on EtoBox.

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## Background and aims: We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (sfe), and its potential anti-inflammatory mechanisms, in apoe knockout (apoe) mice. ## Methods: Fifty male, apoe mice, fed a high-fat diet (hfd) for 12 weeks, were randomized into 5 groups: (1) baseline group, euthanatized, without intervention, (2) three saffron groups, receiving hfd and 30,60,90 mg/kg/day of sfe, respectively, for four weeks, per os through gavage, after reconstitution in water for injection (wfi), (3) control group (cog), receiving daily hfd and the same volume of wfi (four weeks). after blood sampling and euthanasia, aortic roots were excised and analyzed for gene expression and/or percentage of aortic stenosis, relative content of macrophages, smooth muscle cells (smcs), connective tissue, tumor necrosis factor-α (tnf-α), monocyte chemoattractant protein-1 (mcp-1), matrix metalloproteinases-2,-3,-9 (mmp-2,-3,-9) and their inhibitor (timp-2) and il-6. sfe doses were determined by a pilot serum pharmacokinetic study in c57bl/6j wild-type mice. ## Results: Sfe did not affect body weight and total cholesterol levels (p > 0.05), while high sfe dose significan

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Author

Ei. Christodoulou; N.P.E. Kadoglou; M. Stasinopoulou; O.A. Konstandi; C. Kenoutis; Z.I. Kakazanis; A. Rizakou; N. Kostomitsopoulos; G. Valsami

Publisher

Elsevier BV

Published

2017

Language

EN

Field

Medicine (Health Sciences)