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The usefulness of magnetic resonance imaging (MRI) for disseminated trichosporosis of the gastrocnemius muscles by Akiko Meguro-Hashimoto; Masaaki Takatoku; Ken Ohmine; Masaki Toshima; Masaki Mori; Tadashi Nagai; Kazuo Muroi; Keiya Ozawa is a Medicine article available to read on EtoBox.

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A 30-year-old man with acute myeloid leukemia who was pancytopenic after undergoing intensive chemotherapy developed pyrexia and severe pain of both lower legs. We immediately started empiric therapy with cefepime, vancomycin, and fluconazole for febrile neutropenia. However, symptoms progressed. After 4 days, Trichosporon was isolated from venous blood cultures. MRI showed hyperintense lesions within both gastrocnemius muscles and demonstrated reactive vasodilatation and interstitial tissue edema, thought to be induced by hyperpermeability of vessel membranes due to the local fungal infection. Amphotericin B was very effective against this organism. Trichosporosis is a rare infectious disease generally occurring in immunocompromized hosts. To the best of our knowledge, this is first reported case of bilateral Trichosporon infection of lower leg muscles. Severe leg pain was one of the most important signs of fungal infection in this patient with hematologic malignancy.

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Author

Akiko Meguro-Hashimoto; Masaaki Takatoku; Ken Ohmine; Masaki Toshima; Masaki Mori; Tadashi Nagai; Kazuo Muroi; Keiya Ozawa

Publisher

Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 0163-4453)

Published

2006

Language

EN

Field

Medicine (Health Sciences)