Can I read Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk on EtoBox?

Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk by Tian, Tian (author);Bi, Haoran (author);Zhang, Ding (author);Liu, Yupeng (author);Sun, Hongru (author);Jia, Chenyang (author);Zheng, Ting (author);Huang, Hao (author);Fu, Jinming (author);Zhu, Lin (author);Zhao, Yashuang (author) is a Medicine article available to read on EtoBox.

What is Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk about?

## Abstract X chromosome change has been proved to be associated with carcinogenesis and related to gender differences in cancer risk. If aberrant methylation of genes encoded by X chromosome involve in the risk and prognosis of cancers, including colorectal cancer (CRC), remain unclear. We conducted a case–control study consisted of 432 CRC cases and 434 controls, detecting the methylation levels of FAM156B, PIH1D3, and PPP1R3F in the X chromosome in blood leukocytes using methylation‐sensitive high‐resolution melting (MS‐HRM). We analyzed the relationship between the methylation levels and CRC susceptibility and then explored the interactions with environmental factors on CRC risk with logistics regression. Moreover, we conducted a follow‐up study containing 225 CRC patients to explore the associations between the methylation of FAM156B, PPP1R3F, and PIH1D3 and CRC prognosis. The hypermethylation of FAM156B, PPP1R3F, and PIH1D3 was related to increased CRC risk (OR~PS‐adj~ = 2.932, 95% confidence interval [CI]: 2.029–4.237; OR~PS‐adj~ = 1.602, 95% CI: 1.078–2.382; OR~PS‐adj~ = 1.628, 95% CI: 1.065–2.490, respectively). In the multiple CpG site methylation (MCSM) analysis, compare

Who reads Methylation of three genes encoded by X chromosome in blood leukocytes and colorectal cancer risk?

Author

Tian, Tian (author);Bi, Haoran (author);Zhang, Ding (author);Liu, Yupeng (author);Sun, Hongru (author);Jia, Chenyang (author);Zheng, Ting (author);Huang, Hao (author);Fu, Jinming (author);Zhu, Lin (author);Zhao, Yashuang (author)

Publisher

Wiley

Published

2021

Language

EN

Field

Medicine (Health Sciences)