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Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease by Keyue Ding; Iftikhar J Kullo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background: We hypothesized that the frequencies of risk alleles of snps mediating susceptibility to cardiovascular diseases differ among populations of varying geographic origin and that population-specific selection has operated on some of these variants. ## Methods: From the database of genome-wide association studies (gwas), we selected 36 cardiovascular phenotypes including coronary heart disease, hypertension, and stroke, as well as related quantitative traits (eg, body mass index and plasma lipid levels). we identified 292 snps in 270 genes associated with a disease or trait at p < 5 × 10−8. as part of the human genome-diversity project (hgdp), 158 (54.1%) of these snps have been genotyped in 938 individuals belonging to 52 populations from seven geographic areas. a measure of population differentiation, f(st), was calculated to quantify differences in risk allele frequencies (rafs) among populations and geographic areas. ## Results: Large differences in rafs were noted in populations of africa, east asia, america and oceania, when compared with other geographic regions. the mean global f(st) (0.1042) for 158 snps among the populations was not significantly higher than th

Who reads Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease?

Author

Keyue Ding; Iftikhar J Kullo

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2350)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)