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Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits by Stephanie Dauth; Ruxandra F Sîrbulescu; Silvia Jordans; Maren Rehders; Linda Avena; Julia Oswald; Alexander Lerchl; Paul Saftig; Klaudia Brix is a Neuroscience article available to read on EtoBox.
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## Background Cathepsin K is a cysteine peptidase known for its importance in osteoclast-mediated bone resorption. Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis. However, side effects of first generation inhibitors included altered levels of related cathepsins in peripheral organs and in the central nervous system (CNS). Cathepsin K has been recently detected in brain parenchyma and it has been linked to neurobehavioral disorders such as schizophrenia. Thus, the study of the functions that cathepsin K fulfils in the brain becomes highly relevant. ## Results Cathepsin K messenger RNA was detectable in all brain regions of wild type (WT) mice. At the protein level, cathepsin K was detected by immunofluorescence microscopy in vesicles of neuronal and non-neuronal cells throughout the mouse brain. The hippocampus of WT mice exhibited the highest levels of cathepsin K activity in fluorogenic assays, while the cortex, striatum, and cerebellum revealed significantly lower enzymatic activities. At the molecular level, the proteolytic network of cysteine cathepsins was disrupted in the brain of cathepsin K-deficient (__Ctsk__^-/-^) animals. Specifically, cat
Who reads Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Stephanie Dauth; Ruxandra F Sîrbulescu; Silvia Jordans; Maren Rehders; Linda Avena; Julia Oswald; Alexander Lerchl; Paul Saftig; Klaudia Brix
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2202)
- Published
- 2011
- Language
- EN
- Field
- Neuroscience (Life Sciences)