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Investigating the Utility of COVID-19 Antibody Testing in End-Stage Renal Disease Patients Receiving Haemodialysis: A Cohort Study in the United Kingdom by Wickens, Olivia (author);Chinnadurai, Rajkumar (author);Mannan, Fahmida (author);Svendsen, Frida (author);Baig, Mirza Y (author);Chukwu, Chukwuma (author);Ali, Ibrahim (author);Summersgill, Christina (author);Evans, Dawn (author);Antoine, Berckley V (author);Oxton, Julie (author);Mairs, Nathan (author);Flanagan, Emma (author);Oliver, Robert (author);Kalra, Philip A (author);Poulikakos, Dimitrios (author) is a scholarly article available to read on EtoBox.

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## Abstract BackgroundEnd-stage renal disease (ESRD) patients receiving haemodialysis (HD) are a vulnerable group of patients with increased mortality from COVID-19. Despite improved understanding, the duration of host immunity following COVID-19 infection and role of serological testing alone or in addition to real-time reverse transcription polymerase chain reaction (rRT-PCR) testing in the HD population is not fully understood, which this study aimed to investigate. MethodsThere were two parts to this study. Between 15^th^ March 2020 to 15^th^ July 2020, patients receiving HD who tested positive on rRT-PCR for SARS-CoV-2 were recruited into the COVID-19 arm, whilst PCR-negative patients were recruited to the epidemiological arm of the Salford Kidney Study (SKS). All patients underwent monthly testing for anti-SARS-CoV-2 antibodies as per routine clinical practice since August 2020. The aims were twofold: firstly, to determine seroprevalence and COVID-19 exposure in the epidemiological arm; secondly, to assess duration of the antibody response in the COVID-19 arm. Baseline characteristics were reviewed between groups. Statistical analysis was performed using SPSS. Mann-Whitney U

Author

Wickens, Olivia (author);Chinnadurai, Rajkumar (author);Mannan, Fahmida (author);Svendsen, Frida (author);Baig, Mirza Y (author);Chukwu, Chukwuma (author);Ali, Ibrahim (author);Summersgill, Christina (author);Evans, Dawn (author);Antoine, Berckley V (author);Oxton, Julie (author);Mairs, Nathan (author);Flanagan, Emma (author);Oliver, Robert (author);Kalra, Philip A (author);Poulikakos, Dimitrios (author)

Publisher

Research Square Platform LLC

Published

2021

Language

EN