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Review by H Maeda; T Yamamoto is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Review about?

Most bacterial and fungal proteases excreted into infected hosts exhibit a wide range of pathogenic potentials ranging from pain, edema or even shock to translocation of bacteria from the site of infection into systemic circulation, thus resulting in septicemia. The basic mechanism or principle common to all these phenomena is explained by kinin generation, either directly from high-and/or low-molecular weight kininogens or indirectly via activation of the bradykinin generating cascade: i.e. Hageman factor •» activated Hageman factor -> prekallikrein •» kallikrein -> highmolecular weight kininogen •» bradykinin. Some bacterial proteases are also involved in activation of other host protease zymogens such as plasminogen, procollagenase (matrix metallo proteases) and proenzymes of the clotting system. Furthermore, most bacterial proteases are not only resistant to plasma protease inhibitors of the hosts, most of which belong to a group of serine protease inhibitors called serpins (serine protease inhibitors), but they also quickly inactivate serpins. Some bacterial proteases may also activate bacterial toxins thus rendering toxigenic pathogenesis. They are also capable of degrading i

Who reads Review?

Author

H Maeda; T Yamamoto

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)