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Role for connexin 26 in metastasis of human malignant melanoma : Communication between melanoma and endothelial cells via connexin 26 by Mamiko Saito-Katsuragi; Hideo Asada; Hironori Niizeki; Fumitaka Katoh; Mikio Masuzawa; Masahiro Tsutsumi; Hiroki Kuniyasu; Akihiko Ito; Hiroshi Nojima; Sachiko Miyagawa is a Medicine article available to read on EtoBox.

What is Role for connexin 26 in metastasis of human malignant melanoma : Communication between melanoma and endothelial cells via connexin 26 about?

## Abstract ## BACKGROUND. Connexins form the intercellular channels of the gap junction and play an integral part in a variety of biological functions, such as maintaining tissue homeostasis, cell growth control, and development. Previously it was demonstrated that the expression of connexin 26 (Cx26) can increase the metastatic potential of mouse melanoma cells. The objective of the study was to investigate the role Cx26 plays in the metastasis of human melanoma cells, focusing on the communication between melanoma cells and endothelial cells. ## METHODS. Immunostaining was used to examine Cx26 expression in the melanoma lesions and in the endothelial cells around the melanoma cell nests. In all, 33 melanomatous tissue samples from 16 patients were studied, as well as nevocellular nevus (NCN) and normal skin samples. Cx26 mRNA and protein expression was also examined in the cultured endothelial cells. A dye‐transfer assay was performed to examine gap junction formation between melanoma cells and endothelial cells. ## RESULTS. Immunohistochemistry demonstrated that Cx26 was clearly expressed by the endothelial cells of the small vessels surrounding the melanoma cell nests as well

Who reads Role for connexin 26 in metastasis of human malignant melanoma : Communication between melanoma and endothelial cells via connexin 26?

Author

Mamiko Saito-Katsuragi; Hideo Asada; Hironori Niizeki; Fumitaka Katoh; Mikio Masuzawa; Masahiro Tsutsumi; Hiroki Kuniyasu; Akihiko Ito; Hiroshi Nojima; Sachiko Miyagawa

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2007

Language

EN

Field

Medicine (Health Sciences)