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Can I read Synthesis and Characterization of Injectable, Thermosensitive, and Biocompatible Acellular Bone Matrix/poly(ethylene Glycol)-poly (ε-Caprolactone)-poly(ethylene Glycol) Hydrogel Composite on EtoBox?
Synthesis and Characterization of Injectable, Thermosensitive, and Biocompatible Acellular Bone Matrix/poly(ethylene Glycol)-poly (ε-Caprolactone)-poly(ethylene Glycol) Hydrogel Composite by Pei-Yan Ni; Min Fan; Zhi-Yong Qian; Jing-Cong Luo; Chang-Yang Gong; Shao-Zhi Fu; Shuai Shi; Feng Luo; Zhi-Ming Yang is a Engineering article available to read on EtoBox.
What is Synthesis and Characterization of Injectable, Thermosensitive, and Biocompatible Acellular Bone Matrix/poly(ethylene Glycol)-poly (ε-Caprolactone)-poly(ethylene Glycol) Hydrogel Composite about?
## Abstract In orthopedic tissue engineering, the extensively applied acellular bone matrix (ABM) can seldom be prefabricated just right to mold the cavity of the diverse defects, might induce severe inflammation on account of the migration of small granules and usually bring the patients great pain in the treatment. In this study, a new injectable thermosensitive ABM/PECE composite with good biocompatibility was designed and prepared by adding the ABM granules into the triblock copolymer poly(ethylene eglycol)‐poly(ε‐caprolactone)‐poly(ethylene eglycol) (PEG‐PCL‐PEG, PECE). The PECE was synthesized by ring‐opening copolymerization and characterized by ^1^H NMR. The ABM was prepared by acellular treatment of natural bone and ground to fine granules. The obtained ABM/PECE composite showed the most important absorption bands of ABM and PECE copolymer in FT‐IR spectroscopy and underwent sol–gel phage transition from solution to nonflowing hydrogel at 37°C. SEM results indicated that the ABM/PECE composite with different ABM contents all presented similar porous 3D structure. ABM/PECE composite presented mild cytotoxicity to rat MSCs __in vitro__ and good biocompatibility in the BALB/c
Who reads Synthesis and Characterization of Injectable, Thermosensitive, and Biocompatible Acellular Bone Matrix/poly(ethylene Glycol)-poly (ε-Caprolactone)-poly(ethylene Glycol) Hydrogel Composite?
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- Author
- Pei-Yan Ni; Min Fan; Zhi-Yong Qian; Jing-Cong Luo; Chang-Yang Gong; Shao-Zhi Fu; Shuai Shi; Feng Luo; Zhi-Ming Yang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)
- Published
- 2011
- Language
- EN
- Field
- Engineering (Physical Sciences)