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Bioartificial injectable cartilage implants from demineralized bone matrix/PVA and related studies in rabbit animal model by Neda Dadgar; Ali Ghiaseddin; Shiva Irani; Seyed Hossein Ahmadi Tafti; Mina Soufi-Zomorrod; Masoud Soleimani is a Engineering article available to read on EtoBox.
What is Bioartificial injectable cartilage implants from demineralized bone matrix/PVA and related studies in rabbit animal model about?
Functional cartilage tissue engineering needs a substantial, easy to handle scaffold with proper mechanical strength to repair defected area in articular cartilage. In this study, we report the development and characterization of demineralized bone matrix (DBM) in with a poly vinyl alcohol (PVA) to have a proper homogenous injectable scaffold. Injectabiliy of the biodegradable scaffolds, degradation rate, swelling ratio compression and tensile mechanical properties, and viability and proliferation of bone marrow mesenchymal stem cells (BM-MSCs) followed by differentiation of them In-vitro and In-vivo seeded within the scaffold were studied. It demonstrated that the PVA 20% could increase significantly (p < 0.05) the biodegradability of DBM after 720 hours.DBM with 20% of PVA scaffold has significantly higher (p < 0.05) compression and tensile mechanical strength and viscosity. SEM images showed a multilayer of cells on DBM scaffold incorporated with PVA 20%.BM-MSCs on scaffolds, DBM+PVA 20% had a significant growth rate (p < 0.0001) compare to 2D and low concentration of PVA after 21 days of culture. Viability of cells was significantly higher (p < 0.05) on DBM+PVA scaffold compare
Who reads Bioartificial injectable cartilage implants from demineralized bone matrix/PVA and related studies in rabbit animal model?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Neda Dadgar; Ali Ghiaseddin; Shiva Irani; Seyed Hossein Ahmadi Tafti; Mina Soufi-Zomorrod; Masoud Soleimani
- Publisher
- SAGE Publications (ISSN 0885-3282)
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)