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Towards reliable reconstruction of the mouse brain corticothalamic connectivity using diffusion MRI by Tanzil Mahmud Arefin; Choong Heon Lee; Zifei Liang; Harikrishna Rallapalli; Youssef Z. Wadghiri; Daniel H. Turnbull; Jiangyang Zhang is a Neuroscience article available to read on EtoBox.
What is Towards reliable reconstruction of the mouse brain corticothalamic connectivity using diffusion MRI about?
Diffusion magnetic resonance imaging (dMRI) tractography has yielded intriguing insights into brain circuits and their relationship to behavior in response to gene mutations or neurological diseases across a number of species. Still, existing tractography approaches suffer from limited sensitivity and specificity, leading to uncertain interpretation of the reconstructed connections. Hence, in this study, we aimed to optimize the imaging and computational pipeline to achieve the best possible spatial overlaps between the tractography and tracer-based axonal projection maps within the mouse brain corticothalamic network. We developed a dMRI-based atlas of the mouse forebrain with structural labels imported from the Allen Mouse Brain Atlas (AMBA). Using the atlas and dMRI tractography, we first reconstructed detailed node-to-node mouse brain corticothalamic structural connectivity matrices using different imaging and tractography parameters. We then investigated the effects of each condition for accurate reconstruction of the corticothalamic projections by quantifying the similarities between the tractography and the tracer data from the Allen Mouse Brain Connectivity Atlas (AMBCA). O
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It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Tanzil Mahmud Arefin; Choong Heon Lee; Zifei Liang; Harikrishna Rallapalli; Youssef Z. Wadghiri; Daniel H. Turnbull; Jiangyang Zhang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)