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Can I read Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model on EtoBox?
Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model by Kris T. C. Hede; Bjørn B. Christensen; Morten L. Olesen; Jesper Skovhus Thomsen; Casper B. Foldager; Wei Seong Toh; Sai Kiang Lim; Martin C. Lind is a Medicine article available to read on EtoBox.
What is Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model about?
## Objective This study evaluated the effects of mesenchymal stem cell-extracellular vesicles (MSC-EVs) on chondrocyte proliferation in vitro and on cartilage repair in vivo following bone marrow stimulation (BMS) of focal chondral defects of the knee. ## Methods Six adult Göttingen minipigs received 2 chondral defects in each knee. The pigs were randomized to treatment with either BMS combined with MSC-EVs or BMS combined with phosphate-buffered saline (PBS). Intraarticular injections MSC-EVs or PBS were performed immediately after closure of the surgical incisions, and at 2 and 4 weeks postoperatively. Repair was evaluated after 6 months with gross examination, histology, histomorphometry, immunohistochemistry, and micro-computed tomography (μCT) analysis of the trabecular bone beneath the defect. ## Results Defects treated with MSC-EVs had more bone in the cartilage defect area than the PBS-treated defects (7.9% vs. 1.5%, P = 0.02). Less than 1% of the repair tissue in both groups was hyaline cartilage. International Cartilage and Joint Preservation Society II histological scoring showed that defects treated with MSC-EVs scored lower on “matrix staining” (20.8 vs. 50.0, P = 0.03
Who reads Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kris T. C. Hede; Bjørn B. Christensen; Morten L. Olesen; Jesper Skovhus Thomsen; Casper B. Foldager; Wei Seong Toh; Sai Kiang Lim; Martin C. Lind
- Publisher
- SAGE Publications
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)