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The document describes the synthesis of (±)-phthalascidin 622, which is an analogue of the antitumor compound phthalascidin 650. Starting from commercially available 3-methylcatechol, a multi-step synthesis was performed to obtain the key intermediate phenolic α-amino-alcohol (±)-16. A Pictet-Spengler reaction between (±)-16 and an N-protected α-amino aldehyde yielded the pentacyclic ring system. Further modifications including oxidation allowed formation of a (±)-phthalascidin 622 analogue.
- Author
- wayok123187
- Language
- EN