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Comprehensive HRD Assays in Ovarian Cancer by k455362444 is a document available to read on EtoBox.

What is Comprehensive HRD Assays in Ovarian Cancer about?

This review discusses the significance of homologous recombination deficiency (HRD) in high-grade serous ovarian cancer (HGSOC), which affects approximately 50% of cases and is linked to sensitivity to PARP inhibitors. It highlights the limitations of current HRD assays and the need for improved diagnostic methods to better assess patient eligibility for treatment. The document also explores genetic alterations, particularly in BRCA1 and BRCA2, and the broader implications of HRD beyond these mutations.

Author

k455362444

Language

EN