About this document
MMP-9 by Shristi Saini is a document available to read on EtoBox.
The study investigates the role of matrix metalloproteinase-9 (MMP-9) in the angiogenic switch during pancreatic islet carcinogenesis in transgenic mice. MMP-9 is found to be crucial for rendering normal islets angiogenic by releasing vascular endothelial growth factor (VEGF), while inhibition of MMP-9 or VEGF signaling significantly reduces angiogenesis and tumor growth. The findings suggest that MMP-9 is a key component in the transition from quiescent vasculature to angiogenesis in tumor development.
- Author
- Shristi Saini
- Language
- EN