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Can I read Functional Neurological Restoration of Amputated Peripheral Nerve Using Biohybrid Regenerative Bioelectronics on EtoBox?
Functional Neurological Restoration of Amputated Peripheral Nerve Using Biohybrid Regenerative Bioelectronics by Amy E. Rochford; Alejandro Carnicer-Lombarte; Malak Kawan; Amy Jin; Sam Hilton; Vincenzo F. Curto; Alexandra L. Rutz; Thomas Moreau; Mark R. N. Kotter; George G. Malliaras; Damiano G. Barone is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Functional Neurological Restoration of Amputated Peripheral Nerve Using Biohybrid Regenerative Bioelectronics about?
The development of neural interfaces with superior biocompatibility and improved tissue integration is vital for treating and restoring neurological functions in the nervous system. A critical factor is to increase the resolution for mapping neuronal inputs onto implants. For this purpose, we have developed a new category of neural interface comprising induced pluripotent stem cell (iPSC)–derived myocytes as biological targets for peripheral nerve inputs that are grafted onto a flexible electrode arrays. We show long-term survival and functional integration of a biohybrid device carrying human iPSC-derived cells with the forearm nerve bundle of freely moving rats, following 4 weeks of implantation. By improving the tissue-electronics interface with an intermediate cell layer, we have demonstrated enhanced resolution and electrical recording in vivo as a first step toward restorative therapies using regenerative bioelectronics.
Who reads Functional Neurological Restoration of Amputated Peripheral Nerve Using Biohybrid Regenerative Bioelectronics?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Amy E. Rochford; Alejandro Carnicer-Lombarte; Malak Kawan; Amy Jin; Sam Hilton; Vincenzo F. Curto; Alexandra L. Rutz; Thomas Moreau; Mark R. N. Kotter; George G. Malliaras; Damiano G. Barone
- Publisher
- American Association for the Advancement of Science
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)