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The Safety and Efficacy of Mesenchymal Stem Cell Therapy in Diabetic Lower Extremity Vascular Disease: a Meta-analysis and Systematic Review by Lewei Jin; Xiancheng Wang; Zhihua Qiao; Yiwen Deng is a Medicine article available to read on EtoBox.
What is The Safety and Efficacy of Mesenchymal Stem Cell Therapy in Diabetic Lower Extremity Vascular Disease: a Meta-analysis and Systematic Review about?
Background aims Several studies have shown the efficacy of mesenchymal stem cell (MSC) therapy for lower extremity vascular disease (LEVD) in diabetic patients, but the results are not consistent. Therefore, the authors conducted a meta-analysis of randomized controlled trials (RCTs) to examine the safety and efficacy of MSC therapy in diabetic patients with LEVD. Methods Eight available databases were searched in both English and Chinese to identify RCTs comparing MSC therapy-based conventional treatment with conventional treatment alone in diabetic patients with LEVD. Three investigators independently screened the literature, extracted the data and assessed the risk bias. Meta-analysis was performed using RevMan 5.4.1 and Stata 14.0. Results A total of 10 studies involving 453 patients were included. Compared with conventional treatment only, patients receiving MSC therapy-based conventional treatment had a higher ulcer healing rate, greater number of reduced ulcers and shorter complete healing time. MSC therapy also increased ankle–brachial index and transcutaneous oxygen pressure. In addition, four of the included studies showed that MSC therapy significantly improved the numbe
Who reads The Safety and Efficacy of Mesenchymal Stem Cell Therapy in Diabetic Lower Extremity Vascular Disease: a Meta-analysis and Systematic Review?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lewei Jin; Xiancheng Wang; Zhihua Qiao; Yiwen Deng
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)
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