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Can I read Uterine leiomyosarcomas with osteoclast-like giant cells associated with high expression of RUNX2 and RANKL on EtoBox?
Uterine leiomyosarcomas with osteoclast-like giant cells associated with high expression of RUNX2 and RANKL by Mika Terasaki; Yasuhiro Terasaki; Kyoko Wakamatsu; Naomi Kuwahara; Koichi Yoneyama; Rieko Kawase; Keisuke Kurose; Etsuko Toda; Yoko Endo; Shinobu Kunugi; Yusuke Kajimoto; Akira Shimizu is a Medicine article available to read on EtoBox.
What is Uterine leiomyosarcomas with osteoclast-like giant cells associated with high expression of RUNX2 and RANKL about?
Uterine leiomyosarcoma (ULMS) with osteoclast-like giant cells (OLGCs) has been reported as a rare phenomenon in ULMS, and its clinico-pathological features and tumorigenesis remain unclear. We recently reported high expression of receptor activator of nuclear factor κB ligand (RANKL) in ULMS with OLGCs. As osteoblasts produce RANKL, in this study, we analyzed the expression of Runt-related transcription factor 2 (RUNX2), a critical transcription factor for osteoblasts, and osteoclast-related proteins in three cases of ULMS with OLGCs as well as five conventional ULMSs and nine leiomyomas. Immunohistochemistry and real-time reverse transcription quantitative polymerase chain reaction analyses showed high expression of RUNX2 and RANKL in ULMS with OLGCs. In these cases, macrophages expressed receptor activator of nuclear factor κB (RANK), and OLGCs expressed osteoclast-related proteins (nuclear factor of activated T cells, cytoplasmic 1 (NFATc1), and cathepsin K). Accumulation sites of cathepsin K-positive OLGCs showed hemorrhagic appearance and degraded type IV collagen. We reviewed reported cases of ULMS with OLGCs, including ours, and found that they presented an aggressive cours
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- Author
- Mika Terasaki; Yasuhiro Terasaki; Kyoko Wakamatsu; Naomi Kuwahara; Koichi Yoneyama; Rieko Kawase; Keisuke Kurose; Etsuko Toda; Yoko Endo; Shinobu Kunugi; Yusuke Kajimoto; Akira Shimizu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)