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Schwann Cell Caveolin-1 Expression Increases During Myelination and Decreases After Axotomy by Daniel D. Mikol; Steven S. Scherer; Sara J. Duckett; Hoylond L. Hong; Eva L. Feldman is a Neuroscience article available to read on EtoBox.

What is Schwann Cell Caveolin-1 Expression Increases During Myelination and Decreases After Axotomy about?

## Abstract The caveolins are a family of related proteins that form the structural framework of caveolae. They have been implicated in the regulation of signal transduction, cell cycle control, and cellular transport processes, particularly cholesterol trafficking. Caveolin‐1 is expressed by a variety of cell types, including Schwann cells, although its expression is greatest in differentiated cell types, such as endothelial cells and adipocytes. In the present work, we characterize caveolin‐1 expression both during rat sciatic nerve development and after axotomy. Schwann cells express little caveolin‐1 on postnatal days 1 and 6. By P30, myelinating Schwann cells express caveolin‐1, which is localized in the outer/abaxonal myelin membranes as well as intracellularly. After axotomy, Schwann cell caveolin‐1 expression in the distal nerve stump decreases as Schwann cells revert to a premyelinating (p75‐positive) phenotype; residual caveolin‐1 within the nerve largely localizes to myelin debris and infiltrating macrophages. We speculate that caveolin‐1 plays a role in the biology of myelinating Schwann cells. GLIA 38:191–199, 2002. © 2002 Wiley‐Liss, Inc.

Who reads Schwann Cell Caveolin-1 Expression Increases During Myelination and Decreases After Axotomy?

Author

Daniel D. Mikol; Steven S. Scherer; Sara J. Duckett; Hoylond L. Hong; Eva L. Feldman

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)

Published

2002

Language

EN

Field

Neuroscience (Life Sciences)