Can I read Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors on EtoBox?

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors by Ignacio Melero; Walter W. Shuford; Stephanie Ashe Newby; Alejandro Aruffo; Jeffrey A. Ledbetter; Karl Erik Hellström; Robert S. Mittler; Lieping Chen is a Medicine article available to read on EtoBox.

What is Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors about?

The 4-1BB glycoprotein is a member of the tumor necrosis factor receptor superfamily and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Expression of 4-1BB is restricted to primed CD4+ and CD8+ T cells, and 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers a dual mitogenic signal for T-cell activation and growth. These observations suggest an important role for 4-1BB in the amplification of T cell-mediated immune responses. We now show that administration of anti-4-1BB monoclonal antibodies can eradicate established large tumors in mice, including the poorly immunogenic Ag104A sarcoma and the highly tumorigenic P815 masto cytoma. The immune response induced by anti-4- 1BB monoclonal antibodies is mediated by both CD8+ and CD4+ T cells and is accompanied by a marked augmentation of tumor-selective cytolytic T-cell activity. Our data suggest that a similar approach may be efficacious for immunotherapy of human cancer.

Who reads Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors?

Author

Ignacio Melero; Walter W. Shuford; Stephanie Ashe Newby; Alejandro Aruffo; Jeffrey A. Ledbetter; Karl Erik Hellström; Robert S. Mittler; Lieping Chen

Publisher

Springer Science and Business Media LLC

Published

1997

Language

EN

Field

Medicine (Health Sciences)