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Adjuvant effect of caffeine on acetylsalicylic acid anti‐nociception: Prostaglandin E2 synthesis determination in carrageenan‐induced peripheral inflammation in rat by Víctor Fernández‐Dueñas; Sílvia Sánchez; Eulàlia Planas; Raquel Poveda is a Medicine article available to read on EtoBox.

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## Abstract In the present study, we report a synergistic interaction between acetylsalicylic acid (ASA) and caffeine (CAF) on the inhibition of nociception in a model of peripheral inflammation in rat; on the contrary no interaction have been found on anti‐inflammatory effects and peripheral prostaglandin E2 (PGE‐2) synthesis inhibition. Acute inflammation was induced by the subplantar injection of carrageenan into the right hind paw, and the effects of the drugs were evaluated from 0 to 5h. Nociception was assessed using the Randall & Selitto test, and the inflammatory response by plethismometry. Oral administration of ASA (10–400mg/kg) induced dose‐related anti‐nociceptive and anti‐inflammatory effects. On the other hand, oral CAF administration (5–50mg/kg) did not show a dose‐related inhibitory effect, neither on the inhibition of nociception nor on the inflammatory response. To analyze a possible interaction between both drugs a dose—response curve to ASA plus a fixed dose of CAF (5mg/kg) was obtained 3h after the injection of carrageenan, when the inflammatory pain peaked. A fixed dose of CAF was able to improve the anti‐nociceptive, but not the anti‐inflammatory, effects of

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Author

Víctor Fernández‐Dueñas; Sílvia Sánchez; Eulàlia Planas; Raquel Poveda

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)

Published

2008

Language

EN

Field

Medicine (Health Sciences)