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The Sandmeyer isatin synthesis is a chemical reaction first reported in 1919 that involves the condensation of chloral, hydroxylamine, and a primary aryl amine to produce isatin derivatives. The reaction proceeds through the formation of an oximino intermediate, which can be cyclized in the presence of a strong acid, yielding valuable compounds used in the synthesis of quinolines, acridines, and indophenazines. However, the reaction does not work with certain substituted anilines, and specific stereoisomers
- Author
- Uttam Pawar
- Language
- EN